Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2066752

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human MAO-A assessed as inhibition of kynuramine to 4-hydroxyquinoline conversion after 20 mins by fluorometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Amine oxidase [flavin-containing] A (CHEMBL1951)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Selected chromone derivatives as inhibitors of monoamine oxidase.
Legoabe LJ, Petzer A, Petzer JP.
Bioorg Med Chem Lett (2012) 22 : 5480 -5484
PubMed 22850212 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.03 5.98

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2062871 1 5.98
CHEMBL2062882 1 5.82
CHEMBL2062872 1 5.66
CHEMBL2062877 1 5.54
CHEMBL2062879 1 5.20
CHEMBL2062873 1 5.19
CHEMBL2062878 1 4.80
CHEMBL2062876 1 4.71
CHEMBL86905 1 4.54
CHEMBL13311 CHROMONE 1 4.40
CHEMBL2062881 1 4.28
CHEMBL2062883 1 4.22
CHEMBL2062874 1 -
CHEMBL2062875 1 -
CHEMBL2062880 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2062871 IC50 = 1040.0 nM 5.98
CHEMBL2062882 IC50 = 1530.0 nM 5.82
CHEMBL2062872 IC50 = 2200.0 nM 5.66
CHEMBL2062877 IC50 = 2900.0 nM 5.54
CHEMBL2062879 IC50 = 6260.0 nM 5.20
CHEMBL2062873 IC50 = 6460.0 nM 5.19
CHEMBL2062878 IC50 = 15800.0 nM 4.80
CHEMBL2062876 IC50 = 19700.0 nM 4.71
CHEMBL86905 IC50 = 28900.0 nM 4.54
CHEMBL13311 CHROMONE IC50 = 39900.0 nM 4.40
CHEMBL2062881 IC50 = 52900.0 nM 4.28
CHEMBL2062883 IC50 = 60600.0 nM 4.22
CHEMBL2062874 IC50 = 103000.0 nM -
CHEMBL2062875 IC50 = 143000.0 nM -
CHEMBL2062880 IC50 = 143000.0 nM -