Assay Detail
Binding
CHEMBL2066761
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Inhibition of swine H+/K+-ATPase after 30 mins by colorimetry
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.33 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064023 | — | — | 1 | 7.96 |
| CHEMBL2064031 | — | — | 1 | 7.89 |
| CHEMBL2064027 | — | — | 1 | 7.80 |
| CHEMBL3217004 | — | — | 1 | 7.80 |
| CHEMBL3217002 | — | — | 1 | 7.77 |
| CHEMBL2064032 | VONOPRAZAN FUMARATE | 4.0 | 1 | 7.72 |
| CHEMBL2064033 | — | — | 1 | 7.70 |
| CHEMBL2064022 | — | — | 1 | 7.52 |
| CHEMBL3217005 | — | — | 1 | 7.47 |
| CHEMBL3215887 | — | — | 1 | 7.34 |
| CHEMBL2064036 | — | — | 1 | 7.34 |
| CHEMBL2064025 | — | — | 1 | 7.29 |
| CHEMBL3217003 | — | — | 1 | 7.12 |
| CHEMBL2064024 | — | — | 1 | 7.11 |
| CHEMBL2064026 | — | — | 1 | 6.96 |
| CHEMBL2064028 | — | — | 1 | 6.77 |
| CHEMBL2064038 | — | — | 1 | 6.64 |
| CHEMBL2064165 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064023 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2064031 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL2064027 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3217004 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3217002 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2064032 | VONOPRAZAN FUMARATE | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL2064033 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2064022 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3217005 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3215887 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2064036 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2064025 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL3217003 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2064024 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL2064026 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2064028 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2064038 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2064165 | — | IC50 | = | 2200.0 | nM | 5.66 |