Assay Detail
Binding
CHEMBL2066852
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of DNMT1 in human HeLa cell nuclear extract assessed as methylated substrate level by ELISA
2
Total Activities
1
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
DNA (cytosine-5)-methyltransferase 1 (CHEMBL1993) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New cytosine derivatives as inhibitors of DNA methylation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 4.66 | 4.66 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2063048 | — | — | 2 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2063048 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL2063048 | — | Inhibition | - | % | - |