Assay Detail
Binding
CHEMBL2067031
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Binding affinity to PPARgamma LBD by fluorescence polarization based competitive binding assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.33 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434063 | — | — | 1 | 7.58 |
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.72 |
| CHEMBL2064741 | — | — | 1 | 6.49 |
| CHEMBL2064743 | — | — | 1 | 5.62 |
| CHEMBL2064742 | — | — | 1 | 5.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434063 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL121 | ROSIGLITAZONE | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2064741 | — | EC50 | = | 325.0 | nM | 6.49 |
| CHEMBL2064743 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2064742 | — | EC50 | = | 5450.0 | nM | 5.26 |