Assay Detail
Binding
CHEMBL2067582
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Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma
14
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Cell Type | KARPAS-299 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of an orally efficacious inhibitor of anaplastic lymphoma kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.23 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064722 | — | — | 2 | 7.70 |
| CHEMBL2064666 | — | — | 1 | 7.70 |
| CHEMBL2064663 | — | — | 1 | 7.52 |
| CHEMBL1642258 | — | — | 1 | 7.52 |
| CHEMBL2064667 | — | — | 2 | 7.40 |
| CHEMBL2064664 | — | — | 2 | 7.40 |
| CHEMBL2042829 | — | — | 1 | 7.35 |
| CHEMBL2064662 | — | — | 1 | 7.19 |
| CHEMBL2064665 | — | — | 1 | 6.92 |
| CHEMBL2064723 | — | — | 2 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064722 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2064666 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL2064663 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1642258 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL2064667 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2064664 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2042829 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2064664 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2064662 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL2064667 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2064665 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2064723 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2064723 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2064722 | — | IC50 | = | 200.0 | nM | 6.70 |