Assay Detail
Binding
CHEMBL2067907
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTORC2-mediated Akt phosphorylation at Ser473 residue in PTEN-deficient human PC3 cells after 2 hrs by Western blot analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | PC-3 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.76 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2064328 | — | — | 1 | 8.52 |
| CHEMBL1972466 | — | — | 1 | 8.00 |
| CHEMBL2064331 | — | — | 1 | 7.39 |
| CHEMBL2064330 | — | — | 1 | 7.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2064328 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1972466 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL2064331 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL2064330 | — | IC50 | = | 76.0 | nM | 7.12 |