Assay Detail
Binding
CHEMBL2071766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CA2 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.83 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.92 |
| CHEMBL23832 | FENAMIC ACID | 1.0 | 1 | 7.42 |
| CHEMBL41028 | — | — | 1 | 7.35 |
| CHEMBL2070213 | — | — | 1 | 6.20 |
| CHEMBL2070209 | — | — | 1 | 5.92 |
| CHEMBL2070202 | — | — | 1 | 5.84 |
| CHEMBL1673089 | — | — | 1 | 5.71 |
| CHEMBL499273 | — | — | 1 | 5.58 |
| CHEMBL2070214 | — | — | 1 | 5.52 |
| CHEMBL2070203 | — | — | 1 | 5.49 |
| CHEMBL2070208 | — | — | 1 | 5.44 |
| CHEMBL2070212 | — | — | 1 | 5.38 |
| CHEMBL467389 | — | — | 1 | 5.37 |
| CHEMBL2070210 | — | — | 1 | 5.36 |
| CHEMBL2070205 | — | — | 1 | 5.36 |
| CHEMBL2070206 | — | — | 1 | 5.34 |
| CHEMBL2070204 | — | — | 1 | 5.28 |
| CHEMBL2070211 | — | — | 1 | 4.54 |
| CHEMBL2070207 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL23832 | FENAMIC ACID | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL41028 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL2070213 | — | Ki | = | 630.0 | nM | 6.20 |
| CHEMBL2070209 | — | Ki | = | 1190.0 | nM | 5.92 |
| CHEMBL2070202 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL1673089 | — | Ki | = | 1930.0 | nM | 5.71 |
| CHEMBL499273 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL2070214 | — | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL2070203 | — | Ki | = | 3270.0 | nM | 5.49 |
| CHEMBL2070208 | — | Ki | = | 3620.0 | nM | 5.44 |
| CHEMBL2070212 | — | Ki | = | 4140.0 | nM | 5.38 |
| CHEMBL467389 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL2070210 | — | Ki | = | 4360.0 | nM | 5.36 |
| CHEMBL2070205 | — | Ki | = | 4350.0 | nM | 5.36 |
| CHEMBL2070206 | — | Ki | = | 4550.0 | nM | 5.34 |
| CHEMBL2070204 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL2070211 | — | Ki | = | 28500.0 | nM | 4.54 |
| CHEMBL2070207 | — | Ki | = | 1820000.0 | nM | - |