Assay Detail
Binding
CHEMBL2071771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Candida albicans beta carbonic anhydrase NCE103 using CO2 as substrate incubated for 6 hrs prior to substrate addition measured for 10 to 100 secs by stopped flow technique
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cryptococcus neoformans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 5.20 | 6.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.88 |
| CHEMBL23832 | FENAMIC ACID | 1.0 | 1 | 5.97 |
| CHEMBL2070210 | — | — | 1 | 5.12 |
| CHEMBL2070211 | — | — | 1 | 5.11 |
| CHEMBL2070213 | — | — | 1 | 5.08 |
| CHEMBL41028 | — | — | 1 | 5.08 |
| CHEMBL2070206 | — | — | 1 | 5.08 |
| CHEMBL2070205 | — | — | 1 | 5.07 |
| CHEMBL2070212 | — | — | 1 | 5.07 |
| CHEMBL2070208 | — | — | 1 | 5.07 |
| CHEMBL467389 | — | — | 1 | 5.06 |
| CHEMBL2070207 | — | — | 1 | 5.05 |
| CHEMBL1673089 | — | — | 1 | 5.05 |
| CHEMBL2070203 | — | — | 1 | 5.03 |
| CHEMBL499273 | — | — | 1 | 5.03 |
| CHEMBL2070204 | — | — | 1 | 4.91 |
| CHEMBL2070209 | — | — | 1 | 4.81 |
| CHEMBL2070202 | — | — | 1 | - |
| CHEMBL2070214 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL23832 | FENAMIC ACID | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL2070210 | — | Ki | = | 7620.0 | nM | 5.12 |
| CHEMBL2070211 | — | Ki | = | 7750.0 | nM | 5.11 |
| CHEMBL2070213 | — | Ki | = | 8400.0 | nM | 5.08 |
| CHEMBL41028 | — | Ki | = | 8280.0 | nM | 5.08 |
| CHEMBL2070206 | — | Ki | = | 8360.0 | nM | 5.08 |
| CHEMBL2070205 | — | Ki | = | 8450.0 | nM | 5.07 |
| CHEMBL2070212 | — | Ki | = | 8440.0 | nM | 5.07 |
| CHEMBL2070208 | — | Ki | = | 8470.0 | nM | 5.07 |
| CHEMBL467389 | — | Ki | = | 8760.0 | nM | 5.06 |
| CHEMBL2070207 | — | Ki | = | 8940.0 | nM | 5.05 |
| CHEMBL1673089 | — | Ki | = | 8810.0 | nM | 5.05 |
| CHEMBL2070203 | — | Ki | = | 9390.0 | nM | 5.03 |
| CHEMBL499273 | — | Ki | = | 9270.0 | nM | 5.03 |
| CHEMBL2070204 | — | Ki | = | 12300.0 | nM | 4.91 |
| CHEMBL2070209 | — | Ki | = | 15600.0 | nM | 4.81 |
| CHEMBL2070202 | — | Ki | > | 20000.0 | nM | - |
| CHEMBL2070214 | — | Ki | > | 20000.0 | nM | - |