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Assay Detail

CHEMBL2071841

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Binding
Inhibition of LIMK2
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

LIM domain kinase 2 (CHEMBL5932)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Modulation of cofilin phosphorylation by inhibition of the Lim family kinases.
He L, Seitz SP, Trainor GL, Tortolani D, Vaccaro W, Poss M, Tarby CM, Tokarski JS, Penhallow B, Hung CY, Attar R, Lin TA.
Bioorg Med Chem Lett (2012) 22 : 5995 -5998
PubMed 22902653 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.58 8.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2070619 1 8.10
CHEMBL2070618 1 7.92
CHEMBL2070497 1 7.80
CHEMBL2070614 1 7.80
CHEMBL2070504 1 7.55
CHEMBL2070615 1 7.42
CHEMBL2070616 1 7.23
CHEMBL2070498 1 6.85
CHEMBL2070503 1 6.77
CHEMBL2070613 1 6.76
CHEMBL2070617 1 6.70
CHEMBL2070612 1 6.61
CHEMBL2070611 1 6.51
CHEMBL2070505 1 6.42
CHEMBL2070502 1 6.12
CHEMBL2070499 1 6.09
CHEMBL2070501 1 5.91
CHEMBL2070493 1 5.91
CHEMBL2070500 1 5.82
CHEMBL2070494 1 5.81
CHEMBL2070496 1 4.30
CHEMBL2070495 1 4.30
CHEMBL2070492 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2070619 IC50 = 8.0 nM 8.10
CHEMBL2070618 IC50 = 12.0 nM 7.92
CHEMBL2070497 IC50 = 16.0 nM 7.80
CHEMBL2070614 IC50 = 16.0 nM 7.80
CHEMBL2070504 IC50 = 28.0 nM 7.55
CHEMBL2070615 IC50 = 38.0 nM 7.42
CHEMBL2070616 IC50 = 59.0 nM 7.23
CHEMBL2070498 IC50 = 141.0 nM 6.85
CHEMBL2070503 IC50 = 171.0 nM 6.77
CHEMBL2070613 IC50 = 173.0 nM 6.76
CHEMBL2070617 IC50 = 202.0 nM 6.70
CHEMBL2070612 IC50 = 245.0 nM 6.61
CHEMBL2070611 IC50 = 311.0 nM 6.51
CHEMBL2070505 IC50 = 382.0 nM 6.42
CHEMBL2070502 IC50 = 760.0 nM 6.12
CHEMBL2070499 IC50 = 810.0 nM 6.09
CHEMBL2070501 IC50 = 1222.0 nM 5.91
CHEMBL2070493 IC50 = 1232.0 nM 5.91
CHEMBL2070500 IC50 = 1531.0 nM 5.82
CHEMBL2070494 IC50 = 1545.0 nM 5.81
CHEMBL2070496 IC50 = 50000.0 nM 4.30
CHEMBL2070495 IC50 = 50000.0 nM 4.30
CHEMBL2070492 IC50 > 12500.0 nM -