Assay Detail
Binding
CHEMBL2071885
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Inhibition of PDE6
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel triazines as potent and selective phosphodiesterase 10A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.98 | 7.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069321 | — | — | 1 | 7.14 |
| CHEMBL2070655 | — | — | 1 | 6.56 |
| CHEMBL2070649 | — | — | 1 | 6.46 |
| CHEMBL2070639 | — | — | 1 | 6.36 |
| CHEMBL2070631 | — | — | 1 | 6.33 |
| CHEMBL2070651 | — | — | 1 | 6.31 |
| CHEMBL2070654 | — | — | 1 | 6.16 |
| CHEMBL2070641 | — | — | 1 | 6.13 |
| CHEMBL2070632 | — | — | 1 | 6.08 |
| CHEMBL2070669 | — | — | 1 | 6.04 |
| CHEMBL2070648 | — | — | 1 | 5.97 |
| CHEMBL2070633 | — | — | 1 | 5.94 |
| CHEMBL2070671 | — | — | 1 | 5.91 |
| CHEMBL2070653 | — | — | 1 | 5.91 |
| CHEMBL2070668 | — | — | 1 | 5.90 |
| CHEMBL2070634 | — | — | 1 | 5.80 |
| CHEMBL2070666 | — | — | 1 | 5.75 |
| CHEMBL2070652 | — | — | 1 | 5.74 |
| CHEMBL2070647 | — | — | 1 | 5.70 |
| CHEMBL2070662 | — | — | 1 | 5.55 |
| CHEMBL2070656 | — | — | 1 | 5.51 |
| CHEMBL2070664 | — | — | 1 | 5.49 |
| CHEMBL2070665 | — | — | 1 | 5.41 |
| CHEMBL2070667 | — | — | 1 | 5.28 |
| CHEMBL2070660 | — | — | 1 | - |
| CHEMBL2070670 | — | — | 1 | - |
| CHEMBL2070663 | — | — | 1 | - |
| CHEMBL2070661 | — | — | 1 | - |
| CHEMBL2070659 | — | — | 1 | - |
| CHEMBL2070658 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069321 | — | IC50 | = | 73.15 | nM | 7.14 |
| CHEMBL2070655 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL2070649 | — | IC50 | = | 349.0 | nM | 6.46 |
| CHEMBL2070639 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL2070631 | — | IC50 | = | 462.0 | nM | 6.33 |
| CHEMBL2070651 | — | IC50 | = | 493.0 | nM | 6.31 |
| CHEMBL2070654 | — | IC50 | = | 693.0 | nM | 6.16 |
| CHEMBL2070641 | — | IC50 | = | 734.0 | nM | 6.13 |
| CHEMBL2070632 | — | IC50 | = | 829.0 | nM | 6.08 |
| CHEMBL2070669 | — | IC50 | = | 909.0 | nM | 6.04 |
| CHEMBL2070648 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL2070633 | — | IC50 | = | 1150.0 | nM | 5.94 |
| CHEMBL2070671 | — | IC50 | = | 1230.0 | nM | 5.91 |
| CHEMBL2070653 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL2070668 | — | IC50 | = | 1260.0 | nM | 5.90 |
| CHEMBL2070634 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL2070666 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL2070652 | — | IC50 | = | 1822.0 | nM | 5.74 |
| CHEMBL2070647 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL2070662 | — | IC50 | = | 2830.0 | nM | 5.55 |
| CHEMBL2070656 | — | IC50 | = | 3120.0 | nM | 5.51 |
| CHEMBL2070664 | — | IC50 | = | 3270.0 | nM | 5.49 |
| CHEMBL2070665 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL2070667 | — | IC50 | = | 5250.0 | nM | 5.28 |
| CHEMBL2070650 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070646 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2070645 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070640 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070657 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070658 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070659 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070661 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2070663 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL2070670 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2070660 | — | IC50 | > | 10000.0 | nM | - |