Assay Detail
Binding
CHEMBL2071924
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Inhibition of AF546-tagged CMG2 R40C mutant binding to AF488-tagged PA E733C mutant incubated for 1 to 3 hrs prior to AF488-tagged PA E733C addition measured after 3 to 4 hrs by FRET assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Phenolic compounds as antiangiogenic CMG2 inhibitors from Costa Rican endophytic fungi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.26 | 6.30 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2070828 | — | — | 1 | 6.30 |
| CHEMBL559789 | — | — | 1 | 6.22 |
| CHEMBL2070829 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2070828 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL559789 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2070829 | — | Inhibition | - | % | - |