Assay Detail
Binding
CHEMBL2071987
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Displacement of [125I]-c(RGDyK) from human integrin alphavbeta3 after 16 hrs by scintillation counting
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Near-infrared fluorescent divalent RGD ligand for integrin αvβ₃-targeted optical imaging.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.79 | 9.55 |
| Ki | 3 | 9.40 | 10.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2071603 | — | — | 2 | 10.37 |
| CHEMBL2071604 | — | — | 2 | 9.18 |
| CHEMBL2071605 | — | — | 2 | 8.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2071603 | — | Ki | = | 0.043 | nM | 10.37 |
| CHEMBL2071603 | — | IC50 | = | 0.281 | nM | 9.55 |
| CHEMBL2071604 | — | Ki | = | 0.663 | nM | 9.18 |
| CHEMBL2071605 | — | Ki | = | 2.27 | nM | 8.64 |
| CHEMBL2071605 | — | IC50 | = | 3.52 | nM | 8.45 |
| CHEMBL2071604 | — | IC50 | = | 4.305 | nM | 8.37 |