Assay Detail
Functional
CHEMBL2072029
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Inhibition of human LAD2 cells degranulation preincubated for 30 mins before streptavidin stimulation measured after 30 mins by measuring beta-hexosaminidase activity
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LAD2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Highly potent aminopyridines as Syk kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.59 | 6.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069349 | — | — | 1 | 6.93 |
| CHEMBL2069355 | — | — | 1 | 6.91 |
| CHEMBL2069359 | — | — | 1 | 6.85 |
| CHEMBL2069357 | — | — | 1 | 6.77 |
| CHEMBL2069350 | — | — | 1 | 6.73 |
| CHEMBL2069360 | — | — | 1 | 6.69 |
| CHEMBL2069356 | — | — | 1 | 6.48 |
| CHEMBL2069358 | — | — | 1 | 6.45 |
| CHEMBL2069354 | — | — | 1 | 6.44 |
| CHEMBL2069351 | — | — | 1 | 6.23 |
| CHEMBL2069353 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069349 | — | IC50 | = | 118.0 | nM | 6.93 |
| CHEMBL2069355 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL2069359 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2069357 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL2069350 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL2069360 | — | IC50 | = | 204.0 | nM | 6.69 |
| CHEMBL2069356 | — | IC50 | = | 331.0 | nM | 6.48 |
| CHEMBL2069358 | — | IC50 | = | 352.0 | nM | 6.45 |
| CHEMBL2069354 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL2069351 | — | IC50 | = | 585.0 | nM | 6.23 |
| CHEMBL2069353 | — | IC50 | = | 1000.0 | nM | 6.00 |