Assay Detail
Functional
CHEMBL2072116
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Antiviral activity against Hepatitis C virus subtype 1a replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.06 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069455 | — | — | 1 | 6.44 |
| CHEMBL2069440 | — | — | 1 | 6.43 |
| CHEMBL2069457 | — | — | 1 | 5.86 |
| CHEMBL2069462 | — | — | 1 | 5.81 |
| CHEMBL2069456 | — | — | 1 | 5.74 |
| CHEMBL2069451 | — | — | 1 | 5.55 |
| CHEMBL2069459 | — | — | 1 | 5.47 |
| CHEMBL2069443 | — | — | 1 | 5.31 |
| CHEMBL2069448 | — | — | 1 | 5.21 |
| CHEMBL2069464 | — | — | 1 | 5.12 |
| CHEMBL2069453 | — | — | 1 | 4.96 |
| CHEMBL2069463 | — | — | 1 | 4.96 |
| CHEMBL2069466 | — | — | 1 | 4.94 |
| CHEMBL2069441 | — | — | 1 | 4.92 |
| CHEMBL2069450 | — | — | 1 | 4.80 |
| CHEMBL2069446 | — | — | 1 | 4.74 |
| CHEMBL2069454 | — | — | 1 | 4.65 |
| CHEMBL2069465 | — | — | 1 | 4.62 |
| CHEMBL2069442 | — | — | 1 | 4.61 |
| CHEMBL2069310 | — | — | 1 | 4.60 |
| CHEMBL2069449 | — | — | 1 | 4.58 |
| CHEMBL2069460 | — | — | 1 | 4.45 |
| CHEMBL2059135 | — | — | 1 | 4.45 |
| CHEMBL2069447 | — | — | 1 | 4.44 |
| CHEMBL2069452 | — | — | 1 | 4.43 |
| CHEMBL2069461 | — | — | 1 | 4.42 |
| CHEMBL2069458 | — | — | 1 | - |
| CHEMBL2069444 | — | — | 1 | - |
| CHEMBL2069445 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069455 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2069440 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2069457 | — | EC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL2069462 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL2069456 | — | EC50 | = | 1830.0 | nM | 5.74 |
| CHEMBL2069451 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2069459 | — | EC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL2069443 | — | EC50 | = | 4910.0 | nM | 5.31 |
| CHEMBL2069448 | — | EC50 | = | 6150.0 | nM | 5.21 |
| CHEMBL2069464 | — | EC50 | = | 7580.0 | nM | 5.12 |
| CHEMBL2069453 | — | EC50 | = | 10940.0 | nM | 4.96 |
| CHEMBL2069463 | — | EC50 | = | 11080.0 | nM | 4.96 |
| CHEMBL2069466 | — | EC50 | = | 11390.0 | nM | 4.94 |
| CHEMBL2069441 | — | EC50 | = | 11990.0 | nM | 4.92 |
| CHEMBL2069450 | — | EC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL2069446 | — | EC50 | = | 18330.0 | nM | 4.74 |
| CHEMBL2069454 | — | EC50 | = | 22360.0 | nM | 4.65 |
| CHEMBL2069465 | — | EC50 | = | 24030.0 | nM | 4.62 |
| CHEMBL2069442 | — | EC50 | = | 24670.0 | nM | 4.61 |
| CHEMBL2069310 | — | EC50 | = | 25160.0 | nM | 4.60 |
| CHEMBL2069449 | — | EC50 | = | 26360.0 | nM | 4.58 |
| CHEMBL2069460 | — | EC50 | = | 35320.0 | nM | 4.45 |
| CHEMBL2059135 | — | EC50 | = | 35430.0 | nM | 4.45 |
| CHEMBL2069447 | — | EC50 | = | 36310.0 | nM | 4.44 |
| CHEMBL2069452 | — | EC50 | = | 36980.0 | nM | 4.43 |
| CHEMBL2069461 | — | EC50 | = | 37750.0 | nM | 4.42 |
| CHEMBL2069458 | — | EC50 | > | 44000.0 | nM | - |
| CHEMBL2069444 | — | EC50 | - | — | - | |
| CHEMBL2069445 | — | EC50 | - | — | - |