Assay Detail
Functional
CHEMBL2072118
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Hepatitis C virus subtype 1b replicons infected in human HuH7 cells assessed as reduction in viral RNA levels by Rt-PCR
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | Huh-7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2'-C-methylribonucleosides, 2'-deoxy-2'-fluoroarabinonucleosides, arabinonucleosides and 2'-deoxyribonucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 5.17 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2069455 | — | — | 1 | 6.44 |
| CHEMBL2069440 | — | — | 1 | 6.42 |
| CHEMBL2069456 | — | — | 1 | 6.04 |
| CHEMBL2069457 | — | — | 1 | 5.86 |
| CHEMBL2069462 | — | — | 1 | 5.76 |
| CHEMBL2069459 | — | — | 1 | 5.52 |
| CHEMBL2069451 | — | — | 1 | 5.39 |
| CHEMBL2069463 | — | — | 1 | 5.38 |
| CHEMBL2069464 | — | — | 1 | 5.29 |
| CHEMBL2069465 | — | — | 1 | 5.28 |
| CHEMBL2069443 | — | — | 1 | 5.28 |
| CHEMBL2069466 | — | — | 1 | 5.23 |
| CHEMBL2069448 | — | — | 1 | 5.21 |
| CHEMBL2069454 | — | — | 1 | 5.07 |
| CHEMBL2069444 | — | — | 1 | 5.05 |
| CHEMBL2069441 | — | — | 1 | 5.03 |
| CHEMBL2069453 | — | — | 1 | 4.97 |
| CHEMBL2069450 | — | — | 1 | 4.92 |
| CHEMBL2069446 | — | — | 1 | 4.91 |
| CHEMBL2069445 | — | — | 1 | 4.85 |
| CHEMBL2069447 | — | — | 1 | 4.81 |
| CHEMBL2069452 | — | — | 1 | 4.77 |
| CHEMBL2069460 | — | — | 1 | 4.68 |
| CHEMBL2069310 | — | — | 1 | 4.65 |
| CHEMBL2069442 | — | — | 1 | 4.62 |
| CHEMBL2059135 | — | — | 1 | 4.57 |
| CHEMBL2069461 | — | — | 1 | 4.47 |
| CHEMBL2069449 | — | — | 1 | 4.36 |
| CHEMBL2069458 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2069455 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL2069440 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2069456 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL2069457 | — | EC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL2069462 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL2069459 | — | EC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL2069451 | — | EC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL2069463 | — | EC50 | = | 4160.0 | nM | 5.38 |
| CHEMBL2069464 | — | EC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL2069465 | — | EC50 | = | 5260.0 | nM | 5.28 |
| CHEMBL2069443 | — | EC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL2069466 | — | EC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL2069448 | — | EC50 | = | 6130.0 | nM | 5.21 |
| CHEMBL2069454 | — | EC50 | = | 8450.0 | nM | 5.07 |
| CHEMBL2069444 | — | EC50 | = | 8960.0 | nM | 5.05 |
| CHEMBL2069441 | — | EC50 | = | 9440.0 | nM | 5.03 |
| CHEMBL2069453 | — | EC50 | = | 10810.0 | nM | 4.97 |
| CHEMBL2069450 | — | EC50 | = | 12050.0 | nM | 4.92 |
| CHEMBL2069446 | — | EC50 | = | 12280.0 | nM | 4.91 |
| CHEMBL2069445 | — | EC50 | = | 14190.0 | nM | 4.85 |
| CHEMBL2069447 | — | EC50 | = | 15540.0 | nM | 4.81 |
| CHEMBL2069452 | — | EC50 | = | 16994.0 | nM | 4.77 |
| CHEMBL2069460 | — | EC50 | = | 20640.0 | nM | 4.68 |
| CHEMBL2069310 | — | EC50 | = | 22470.0 | nM | 4.65 |
| CHEMBL2069442 | — | EC50 | = | 24130.0 | nM | 4.62 |
| CHEMBL2059135 | — | EC50 | = | 27070.0 | nM | 4.57 |
| CHEMBL2069461 | — | EC50 | = | 33980.0 | nM | 4.47 |
| CHEMBL2069449 | — | EC50 | = | 43470.0 | nM | 4.36 |
| CHEMBL2069458 | — | EC50 | > | 44000.0 | nM | - |