Assay Detail
Functional
CHEMBL2072333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania major promastigotes incubated for 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania major |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Leishmanicidal activities and cytotoxicities of bisnaphthoquinone analogues and naphthol derivatives from Burman Diospyros burmanica.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.99 | 10.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | 10.46 |
| CHEMBL2071225 | BURMANIN A | — | 1 | 10.28 |
| CHEMBL2071223 | BURMANIN C | — | 1 | 9.82 |
| CHEMBL2071226 | BURMANIN B | — | 1 | 9.74 |
| CHEMBL1531003 | — | — | 1 | 5.48 |
| CHEMBL2071229 | — | — | 1 | 4.42 |
| CHEMBL2071227 | — | — | 1 | 4.35 |
| CHEMBL2071228 | — | — | 1 | 4.30 |
| CHEMBL2071233 | — | — | 1 | 4.03 |
| CHEMBL2071224 | — | — | 1 | - |
| CHEMBL2071230 | — | — | 1 | - |
| CHEMBL2071231 | — | — | 1 | - |
| CHEMBL2071232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267345 | AMPHOTERICIN B | IC50 | = | 0.035 | nM | 10.46 |
| CHEMBL2071225 | BURMANIN A | IC50 | = | 0.053 | nM | 10.28 |
| CHEMBL2071223 | BURMANIN C | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL2071226 | BURMANIN B | IC50 | = | 0.18 | nM | 9.74 |
| CHEMBL1531003 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL2071229 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL2071227 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL2071228 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2071233 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL2071224 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2071230 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2071231 | — | IC50 | - | — | - | |
| CHEMBL2071232 | — | IC50 | > | 100000.0 | nM | - |