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Assay Detail

CHEMBL2072871

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Functional
Antiplasmodial activity against Plasmodium falciparum 3D7 ring stage cells assessed as reduction parasitemia by Malstat assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.
Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K.
Bioorg Med Chem (2012) 20 : 5277 -5289
PubMed 22858300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 6.42 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL76 CHLOROQUINE 4.0 1 7.52
CHEMBL99254 1 7.52
CHEMBL2071262 1 7.52
CHEMBL307261 ARTENIMOL 3.0 1 7.52
CHEMBL2071266 1 6.89
CHEMBL2071261 1 6.80
CHEMBL2071264 1 6.66
CHEMBL2071268 1 6.57
CHEMBL2071263 1 6.57
CHEMBL2071269 TETRAOXANE 1 6.50
CHEMBL2071254 1 6.43
CHEMBL2071258 1 6.42
CHEMBL2071260 1 6.34
CHEMBL2071255 1 6.24
CHEMBL2071265 1 5.85
CHEMBL2071259 1 5.71
CHEMBL31000 1 5.66
CHEMBL2071256 1 5.45
CHEMBL2071257 1 5.29
CHEMBL2071267 1 4.95
CHEMBL129 ZIDOVUDINE 4.0 1 -
CHEMBL254316 RALTEGRAVIR 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL76 CHLOROQUINE IC50 = 30.0 nM 7.52
CHEMBL99254 IC50 = 30.0 nM 7.52
CHEMBL2071262 IC50 = 30.0 nM 7.52
CHEMBL307261 ARTENIMOL IC50 = 30.0 nM 7.52
CHEMBL2071266 IC50 = 130.0 nM 6.89
CHEMBL2071261 IC50 = 160.0 nM 6.80
CHEMBL2071264 IC50 = 220.0 nM 6.66
CHEMBL2071268 IC50 = 270.0 nM 6.57
CHEMBL2071263 IC50 = 270.0 nM 6.57
CHEMBL2071269 TETRAOXANE IC50 = 320.0 nM 6.50
CHEMBL2071254 IC50 = 370.0 nM 6.43
CHEMBL2071258 IC50 = 380.0 nM 6.42
CHEMBL2071260 IC50 = 460.0 nM 6.34
CHEMBL2071255 IC50 = 580.0 nM 6.24
CHEMBL2071265 IC50 = 1420.0 nM 5.85
CHEMBL2071259 IC50 = 1940.0 nM 5.71
CHEMBL31000 IC50 = 2200.0 nM 5.66
CHEMBL2071256 IC50 = 3530.0 nM 5.45
CHEMBL2071257 IC50 = 5180.0 nM 5.29
CHEMBL2071267 IC50 = 11120.0 nM 4.95
CHEMBL129 ZIDOVUDINE IC50 - -
CHEMBL254316 RALTEGRAVIR IC50 - -