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Assay Detail

CHEMBL2072872

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against drug resistant Plasmodium falciparum Dd2 ring stage cells assessed as reduction parasitemia by Malstat assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy.
Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K.
Bioorg Med Chem (2012) 20 : 5277 -5289
PubMed 22858300 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.38 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2071262 1 8.00
CHEMBL307261 ARTENIMOL 3.0 1 8.00
CHEMBL2071255 1 7.10
CHEMBL2071258 1 7.10
CHEMBL2071264 1 7.00
CHEMBL2071263 1 7.00
CHEMBL2071269 TETRAOXANE 1 6.92
CHEMBL2071268 1 6.72
CHEMBL2071261 1 6.66
CHEMBL2071266 1 6.64
CHEMBL99254 1 6.64
CHEMBL2071254 1 6.47
CHEMBL2071260 1 6.19
CHEMBL76 CHLOROQUINE 4.0 1 6.15
CHEMBL2071265 1 5.84
CHEMBL31000 1 5.76
CHEMBL2071257 1 5.10
CHEMBL2071259 1 4.98
CHEMBL2071267 1 4.92
CHEMBL2071256 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2071262 IC50 = 10.0 nM 8.00
CHEMBL307261 ARTENIMOL IC50 = 10.0 nM 8.00
CHEMBL2071255 IC50 = 80.0 nM 7.10
CHEMBL2071258 IC50 = 80.0 nM 7.10
CHEMBL2071264 IC50 = 100.0 nM 7.00
CHEMBL2071263 IC50 = 100.0 nM 7.00
CHEMBL2071269 TETRAOXANE IC50 = 120.0 nM 6.92
CHEMBL2071268 IC50 = 190.0 nM 6.72
CHEMBL2071261 IC50 = 220.0 nM 6.66
CHEMBL2071266 IC50 = 230.0 nM 6.64
CHEMBL99254 IC50 = 230.0 nM 6.64
CHEMBL2071254 IC50 = 340.0 nM 6.47
CHEMBL2071260 IC50 = 650.0 nM 6.19
CHEMBL76 CHLOROQUINE IC50 = 710.0 nM 6.15
CHEMBL2071265 IC50 = 1460.0 nM 5.84
CHEMBL31000 IC50 = 1720.0 nM 5.76
CHEMBL2071257 IC50 = 8020.0 nM 5.10
CHEMBL2071259 IC50 = 10570.0 nM 4.98
CHEMBL2071267 IC50 = 12100.0 nM 4.92
CHEMBL2071256 IC50 = 31600.0 nM 4.50