Assay Detail
Functional
CHEMBL2072933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human PPARalpha
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting peroxisome proliferator-activated receptors (PPARs): development of modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.79 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL219586 | GW590735 | 2.0 | 1 | 8.40 |
| CHEMBL278590 | GSK-9578 | — | 1 | 8.22 |
| CHEMBL21241 | GW7647 | — | 1 | 7.30 |
| CHEMBL107789 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL219586 | GW590735 | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL278590 | GSK-9578 | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL21241 | GW7647 | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL107789 | — | EC50 | = | 60.0 | nM | 7.22 |