Assay Detail
ADMET
CHEMBL2072969
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Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | SK-BR-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.77 | 9.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 9.04 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.72 |
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.19 |
| CHEMBL49642 | INDIBULIN | 2.0 | 1 | 7.48 |
| CHEMBL9514 | NOCODAZOLE | 2.0 | 1 | 7.08 |
| CHEMBL20684 | ABT-751 | 2.0 | 1 | 6.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL107 | COLCHICINE | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL49642 | INDIBULIN | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL9514 | NOCODAZOLE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL20684 | ABT-751 | IC50 | = | 740.0 | nM | 6.13 |