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Assay Detail

CHEMBL2072979

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Functional
Antiparasitic activity against Toxoplasma gondii grown on human fibroblast layer assessed as inhibition of invasion into fibroblast after 44 hrs by beta-glucosidase assay
ChEMBL ↗
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Toxoplasma gondii
Confidence 1 — Organism
Curated By Autocuration

Target

Toxoplasma gondii (CHEMBL612888) ↗
Type ORGANISM
Organism Toxoplasma gondii

Publication

Development of Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) inhibitors with potent anti-toxoplasma activity.
Johnson SM, Murphy RC, Geiger JA, DeRocher AE, Zhang Z, Ojo KK, Larson ET, Perera BG, Dale EJ, He P, Reid MC, Fox AM, Mueller NR, Merritt EA, Fan E, Parsons M, Van Voorhis WC, Maly DJ.
J Med Chem (2012) 55 : 2416 -2426
PubMed 22320388 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 66 6.89 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2069944 — — 1 8.52
CHEMBL2070062 — — 1 8.48
CHEMBL2070054 — — 1 8.00
CHEMBL2070046 — — 1 8.00
CHEMBL2070066 — — 1 7.92
CHEMBL2070068 — — 1 7.89
CHEMBL2070048 — — 1 7.75
CHEMBL2070045 — — 1 7.68
CHEMBL2070079 — — 1 7.54
CHEMBL2070080 — — 1 7.46
CHEMBL2069941 — — 1 7.39
CHEMBL2069951 — — 1 7.36
CHEMBL2070074 — — 1 7.35
CHEMBL2070086 — — 1 7.31
CHEMBL2070075 — — 1 7.30
CHEMBL2070050 — — 1 7.28
CHEMBL2070051 — — 1 7.24
CHEMBL2070061 — — 1 7.22
CHEMBL2069956 — — 1 7.14
CHEMBL2069943 — — 1 7.10
CHEMBL2070060 — — 1 7.05
CHEMBL2070076 — — 1 7.05
CHEMBL2070087 — — 1 7.00
CHEMBL2070067 — — 1 7.00
CHEMBL2069961 — — 1 6.96
CHEMBL2069950 — — 1 6.92
CHEMBL2069315 — — 1 6.92
CHEMBL2069952 — — 1 6.92
CHEMBL2070063 — — 1 6.89
CHEMBL2070085 — — 1 6.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2069944 — EC50 = 3.0 nM 8.52
CHEMBL2070062 — EC50 = 3.3 nM 8.48
CHEMBL2070054 — EC50 = 10.0 nM 8.00
CHEMBL2070046 — EC50 = 10.0 nM 8.00
CHEMBL2070066 — EC50 = 12.0 nM 7.92
CHEMBL2070068 — EC50 = 13.0 nM 7.89
CHEMBL2070048 — EC50 = 18.0 nM 7.75
CHEMBL2070045 — EC50 = 21.0 nM 7.68
CHEMBL2070079 — EC50 = 29.0 nM 7.54
CHEMBL2070080 — EC50 = 35.0 nM 7.46
CHEMBL2069941 — EC50 = 41.0 nM 7.39
CHEMBL2069951 — EC50 = 44.0 nM 7.36
CHEMBL2070074 — EC50 = 45.0 nM 7.35
CHEMBL2070086 — EC50 = 49.0 nM 7.31
CHEMBL2070075 — EC50 = 50.0 nM 7.30
CHEMBL2070050 — EC50 = 52.0 nM 7.28
CHEMBL2070051 — EC50 = 58.0 nM 7.24
CHEMBL2070061 — EC50 = 60.0 nM 7.22
CHEMBL2069956 — EC50 = 72.0 nM 7.14
CHEMBL2069943 — EC50 = 80.0 nM 7.10
CHEMBL2070060 — EC50 = 90.0 nM 7.05
CHEMBL2070076 — EC50 = 90.0 nM 7.05
CHEMBL2070087 — EC50 = 100.0 nM 7.00
CHEMBL2070067 — EC50 = 100.0 nM 7.00
CHEMBL2069961 — EC50 = 110.0 nM 6.96
CHEMBL2069950 — EC50 = 120.0 nM 6.92
CHEMBL2069952 — EC50 = 120.0 nM 6.92
CHEMBL2069315 — EC50 = 120.0 nM 6.92
CHEMBL2070063 — EC50 = 130.0 nM 6.89
CHEMBL2070085 — EC50 = 140.0 nM 6.85
CHEMBL2070064 — EC50 = 140.0 nM 6.85
CHEMBL2070081 — EC50 = 140.0 nM 6.85
CHEMBL2069946 — EC50 = 150.0 nM 6.82
CHEMBL2070077 — EC50 = 160.0 nM 6.80
CHEMBL2070056 — EC50 = 160.0 nM 6.80
CHEMBL2070088 — EC50 = 180.0 nM 6.75
CHEMBL2070083 — EC50 = 200.0 nM 6.70
CHEMBL2070059 — EC50 = 210.0 nM 6.68
CHEMBL2069938 — EC50 = 230.0 nM 6.64
CHEMBL2069948 — EC50 = 270.0 nM 6.57
CHEMBL2070057 — EC50 = 310.0 nM 6.51
CHEMBL2070052 — EC50 = 330.0 nM 6.48
CHEMBL2070082 — EC50 = 330.0 nM 6.48
CHEMBL2070078 — EC50 = 340.0 nM 6.47
CHEMBL2069957 — EC50 = 350.0 nM 6.46
CHEMBL2070047 — EC50 = 410.0 nM 6.39
CHEMBL2070069 — EC50 = 460.0 nM 6.34
CHEMBL2070053 — EC50 = 500.0 nM 6.30
CHEMBL2069940 — EC50 = 510.0 nM 6.29
CHEMBL2069959 — EC50 = 520.0 nM 6.28