Assay Detail
Binding
CHEMBL2072996
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-tagged PI3K p110gamma using [32P]ATP after 60 mins by scintillation proximity assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.73 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2071341 | — | — | 1 | 7.70 |
| CHEMBL2071329 | — | — | 1 | 7.50 |
| CHEMBL2071342 | — | — | 1 | 7.44 |
| CHEMBL2071328 | — | — | 1 | 7.24 |
| CHEMBL2071331 | — | — | 1 | 7.21 |
| CHEMBL2071332 | — | — | 1 | 7.21 |
| CHEMBL2069328 | — | — | 1 | 7.06 |
| CHEMBL2071326 | — | — | 1 | 6.96 |
| CHEMBL2071333 | — | — | 1 | 6.96 |
| CHEMBL2071340 | — | — | 1 | 6.92 |
| CHEMBL2071330 | — | — | 1 | 6.74 |
| CHEMBL2071327 | — | — | 1 | 6.64 |
| CHEMBL2071334 | — | — | 1 | 6.58 |
| CHEMBL2071338 | — | — | 1 | 6.28 |
| CHEMBL1986603 | — | — | 1 | 5.99 |
| CHEMBL2071337 | — | — | 1 | 5.94 |
| CHEMBL2071336 | — | — | 1 | 5.51 |
| CHEMBL2071335 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2071341 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2071329 | — | Ki | = | 32.0 | nM | 7.50 |
| CHEMBL2071342 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2071328 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL2071331 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL2071332 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2069328 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL2071326 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2071333 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL2071340 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2071330 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL2071327 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL2071334 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL2071338 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL1986603 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL2071337 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL2071336 | — | Ki | = | 3060.0 | nM | 5.51 |
| CHEMBL2071335 | — | Ki | = | 5810.0 | nM | 5.24 |