Assay Detail
Binding
CHEMBL2072998
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant GST-tagged PI3K p110delta using [32P]ATP after 60 mins by scintillation proximity assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (CHEMBL3130) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.78 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2071340 | — | — | 1 | 8.52 |
| CHEMBL1986603 | — | — | 1 | 8.40 |
| CHEMBL2071333 | — | — | 1 | 7.72 |
| CHEMBL2071329 | — | — | 1 | 7.21 |
| CHEMBL2071332 | — | — | 1 | 7.13 |
| CHEMBL2071328 | — | — | 1 | 7.10 |
| CHEMBL2071331 | — | — | 1 | 7.10 |
| CHEMBL2071327 | — | — | 1 | 6.72 |
| CHEMBL2071326 | — | — | 1 | 6.68 |
| CHEMBL2071338 | — | — | 1 | 6.66 |
| CHEMBL2071330 | — | — | 1 | 6.61 |
| CHEMBL2071334 | — | — | 1 | 6.58 |
| CHEMBL2071341 | — | — | 1 | 6.42 |
| CHEMBL2071342 | — | — | 1 | 6.33 |
| CHEMBL2069328 | — | — | 1 | 6.13 |
| CHEMBL2071337 | — | — | 1 | 5.78 |
| CHEMBL2071336 | — | — | 1 | 5.54 |
| CHEMBL2071335 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2071340 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1986603 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2071333 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL2071329 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2071332 | — | Ki | = | 74.0 | nM | 7.13 |
| CHEMBL2071328 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL2071331 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL2071327 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL2071326 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL2071338 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL2071330 | — | Ki | = | 247.0 | nM | 6.61 |
| CHEMBL2071334 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL2071341 | — | Ki | = | 380.0 | nM | 6.42 |
| CHEMBL2071342 | — | Ki | = | 470.0 | nM | 6.33 |
| CHEMBL2069328 | — | Ki | = | 740.0 | nM | 6.13 |
| CHEMBL2071337 | — | Ki | = | 1670.0 | nM | 5.78 |
| CHEMBL2071336 | — | Ki | = | 2900.0 | nM | 5.54 |
| CHEMBL2071335 | — | Ki | = | 3620.0 | nM | 5.44 |