Assay Detail
Binding
CHEMBL2073515
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Inhibition of Neisseria meningitidis MTAN assessed as reduction in methylthioadenosine phosphorolysis/hydrolysi
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Neisseria meningitidis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 8.26 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405346 | — | — | 1 | 9.85 |
| CHEMBL1195586 | — | — | 1 | 9.44 |
| CHEMBL2070307 | — | — | 1 | 9.10 |
| CHEMBL2070311 | — | — | 1 | 9.05 |
| CHEMBL2070310 | — | — | 1 | 8.92 |
| CHEMBL2070401 | — | — | 1 | 8.74 |
| CHEMBL2070402 | — | — | 1 | 8.40 |
| CHEMBL2070404 | — | — | 1 | 8.30 |
| CHEMBL2070312 | — | — | 1 | 8.22 |
| CHEMBL2070400 | — | — | 1 | 8.00 |
| CHEMBL2070403 | — | — | 1 | 7.44 |
| CHEMBL2070408 | — | — | 1 | 7.33 |
| CHEMBL2070405 | — | — | 1 | 7.21 |
| CHEMBL2070407 | — | — | 1 | 7.07 |
| CHEMBL2070406 | — | — | 1 | 6.88 |
| CHEMBL2070309 | — | — | 1 | - |
| CHEMBL2070308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405346 | — | Ki | = | 0.14 | nM | 9.85 |
| CHEMBL1195586 | — | Ki | = | 0.36 | nM | 9.44 |
| CHEMBL2070307 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL2070311 | — | Ki | = | 0.9 | nM | 9.05 |
| CHEMBL2070310 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL2070401 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL2070402 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL2070404 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL2070312 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL2070400 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL2070403 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL2070408 | — | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL2070405 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL2070407 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL2070406 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL2070309 | — | Ki | - | — | - | |
| CHEMBL2070308 | — | Ki | - | — | - |