Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2073536

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human SK-N-MC cells after 72 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SK-N-MC
Confidence 1 — Organism
Curated By Autocuration

Target

SK-N-MC (CHEMBL614163)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy.
Serda M, Kalinowski DS, Mrozek-Wilczkiewicz A, Musiol R, Szurko A, Ratuszna A, Pantarat N, Kovacevic Z, Merlot AM, Richardson DR, Polanski J.
Bioorg Med Chem Lett (2012) 22 : 5527 -5531
PubMed 22858101 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.16 7.85

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL385064 1 7.85
CHEMBL2070545 1 6.96
CHEMBL2070546 1 6.72
CHEMBL2070547 1 6.21
CHEMBL1096926 1 6.09
CHEMBL390195 1 5.89
CHEMBL2070441 1 5.79
CHEMBL2070442 1 5.01
CHEMBL556 DEFEROXAMINE 4.0 1 4.90
CHEMBL1094607 1 -
CHEMBL2070447 1 -
CHEMBL2070446 1 -
CHEMBL2070445 1 -
CHEMBL2070444 1 -
CHEMBL2070443 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL385064 IC50 = 14.0 nM 7.85
CHEMBL2070545 IC50 = 110.0 nM 6.96
CHEMBL2070546 IC50 = 190.0 nM 6.72
CHEMBL2070547 IC50 = 620.0 nM 6.21
CHEMBL1096926 IC50 = 810.0 nM 6.09
CHEMBL390195 IC50 = 1300.0 nM 5.89
CHEMBL2070441 IC50 = 1630.0 nM 5.79
CHEMBL2070442 IC50 = 9690.0 nM 5.01
CHEMBL556 DEFEROXAMINE IC50 = 12500.0 nM 4.90
CHEMBL1094607 IC50 > 12500.0 nM -
CHEMBL2070447 IC50 > 12500.0 nM -
CHEMBL2070446 IC50 > 12500.0 nM -
CHEMBL2070445 IC50 > 12500.0 nM -
CHEMBL2070444 IC50 > 12500.0 nM -
CHEMBL2070443 IC50 > 12500.0 nM -