Assay Detail
Functional
CHEMBL2075305
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Adrenaline uptake in OCT2-expressing HEK293 cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 2 (CHEMBL1770032) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Transport of monoamine transmitters by the organic cation transporter type 2, OCT2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 2 | 7.15 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339858 | DISPROCYNIUM24 | — | 1 | 7.92 |
| CHEMBL110739 | CORTICOSTERONE | 3.0 | 1 | 6.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339858 | DISPROCYNIUM24 | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL110739 | CORTICOSTERONE | Ki | = | 420.0 | nM | 6.38 |