Assay Detail

CHEMBL2075311

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Functional

TP_TRANSPORTER: inhibition of PGD2 uptake in Xenopus laevis oocytes

ChEMBL ↗

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Target

Solute carrier organic anion transporter family member 2B1 (CHEMBL2073698) ↗

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Solute carrier organic anion transporter family member 2B1 (CHEMBL2073698) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Solute carrier organic anion transporter family member 2B1

CHEMBL2073698

Anchored from Assay target.

Protein identity Solute carrier organic anion transporter family member 2B1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Xenopus laevis
Cell Type	Oocyte
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Solute carrier organic anion transporter family member 2B1 (CHEMBL2073698) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate.

Nishio T, Adachi H, Nakagomi R, Tokui T, Sato E, Tanemoto M, Fujiwara K, Okabe M, Onogawa T, Suzuki T, Nakai D, Shiiba K, Suzuki M, Ohtani H, Kondo Y, Unno M, Ito S, Iinuma K, Nunoki K, Matsuno S, Abe T.
Biochem Biophys Res Commun (2000) 275 : 831 -838
PubMed 10973807 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	7.00	7.45

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL495	ALPROSTADIL	4.0	1	7.45
CHEMBL815	DINOPROST	4.0	1	6.54

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL495	ALPROSTADIL	IC50	=	35.8	nM	7.45
CHEMBL815	DINOPROST	IC50	=	287.0	nM	6.54