Assay Detail
Functional
CHEMBL2075764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Digoxin uptake in OATP4C1-expressing MDCK cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier organic anion transporter family member 4C1 (CHEMBL2073690) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.62 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL254219 | DIGITOXIN | 4.0 | 1 | 6.92 |
| CHEMBL1153 | DIGOXIGENIN | — | 1 | 6.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL254219 | DIGITOXIN | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL1153 | DIGOXIGENIN | IC50 | = | 490.0 | nM | 6.31 |