Assay Detail
Functional
CHEMBL2076042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells
10
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | COS |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Ileal sodium/bile acid cotransporter (CHEMBL2778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.84 | 5.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL240597 | CHENODIOL | 4.0 | 1 | 5.48 |
| CHEMBL185878 | TAUROCHENODEOXYCHOLATE | — | 1 | 5.21 |
| CHEMBL406393 | DEOXYCHOLIC ACID | 4.0 | 2 | 5.20 |
| CHEMBL412272 | TAURODEOXYCHOLIC ACID | 2.0 | 1 | 4.76 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 4.62 |
| CHEMBL272427 | TAURURSODIOL | 4.0 | 1 | 4.55 |
| CHEMBL224867 | TAUROCHOLIC ACID | — | 1 | 4.38 |
| CHEMBL1551 | URSODIOL | 4.0 | 1 | 4.12 |
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL240597 | CHENODIOL | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL185878 | TAUROCHENODEOXYCHOLATE | Ki | = | 6100.0 | nM | 5.21 |
| CHEMBL406393 | DEOXYCHOLIC ACID | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL406393 | DEOXYCHOLIC ACID | Ki | = | 6300.0 | nM | 5.20 |
| CHEMBL412272 | TAURODEOXYCHOLIC ACID | Ki | = | 17200.0 | nM | 4.76 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL272427 | TAURURSODIOL | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL224867 | TAUROCHOLIC ACID | Ki | = | 41500.0 | nM | 4.38 |
| CHEMBL1551 | URSODIOL | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | Ki | = | 144000.0 | nM | - |