Assay Detail
Functional
CHEMBL2076229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: increase in Vinblastine intracellular accumulation in MDR1-expressing LLC-PK1 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | LLC-PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 4.94 | 6.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL772 | RESERPINE | 4.0 | 1 | 6.01 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.89 |
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 5.40 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 5.28 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 1 | 5.19 |
| CHEMBL446315 | ERGOCRISTINE | — | 1 | 4.88 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 1 | 4.85 |
| CHEMBL601773 | DIHYDROERGOCRISTINE | -1.0 | 1 | 4.80 |
| CHEMBL1743263 | DIHYDROERGOCRYPTINE | -1.0 | 1 | 4.70 |
| CHEMBL1385840 | ERGOCORNINE | — | 1 | 4.61 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.58 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.52 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 4.42 |
| CHEMBL564085 | TROLEANDOMYCIN | 4.0 | 1 | 4.06 |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 1 | - |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | - |
| CHEMBL119443 | ERGONOVINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL772 | RESERPINE | Ki | = | 970.0 | nM | 6.01 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 3960.0 | nM | 5.40 |
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 5270.0 | nM | 5.28 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 6430.0 | nM | 5.19 |
| CHEMBL446315 | ERGOCRISTINE | Ki | = | 13330.0 | nM | 4.88 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 14250.0 | nM | 4.85 |
| CHEMBL601773 | DIHYDROERGOCRISTINE | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL1743263 | DIHYDROERGOCRYPTINE | Ki | = | 19820.0 | nM | 4.70 |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 24500.0 | nM | 4.61 |
| CHEMBL91 | MICONAZOLE | Ki | = | 26360.0 | nM | 4.58 |
| CHEMBL104 | CLOTRIMAZOLE | Ki | = | 29920.0 | nM | 4.52 |
| CHEMBL532 | ERYTHROMYCIN | Ki | = | 37790.0 | nM | 4.42 |
| CHEMBL564085 | TROLEANDOMYCIN | Ki | = | 87640.0 | nM | 4.06 |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | = | 119940.0 | nM | - |
| CHEMBL106 | FLUCONAZOLE | Ki | > | 400000.0 | nM | - |
| CHEMBL119443 | ERGONOVINE | Ki | > | 100000.0 | nM | - |