Assay Detail
Functional
CHEMBL2076230
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation in MDR1-expressing LLC-PK1 cells
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | LLC-PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 17 | 4.70 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL493 | BROMOCRIPTINE | 4.0 | 1 | 5.55 |
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.33 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 4.91 |
| CHEMBL1403281 | ERGOCRYPTINE | — | 1 | 4.91 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | 4.60 |
| CHEMBL446315 | ERGOCRISTINE | — | 1 | 4.37 |
| CHEMBL104 | CLOTRIMAZOLE | 4.0 | 1 | 4.36 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | 4.26 |
| CHEMBL442 | ERGOTAMINE | 4.0 | 1 | 4.00 |
| CHEMBL119443 | ERGONOVINE | 3.0 | 1 | - |
| CHEMBL1385840 | ERGOCORNINE | — | 1 | - |
| CHEMBL1743263 | DIHYDROERGOCRYPTINE | -1.0 | 1 | - |
| CHEMBL1732 | DIHYDROERGOTAMINE | 4.0 | 1 | - |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | - |
| CHEMBL106 | FLUCONAZOLE | 4.0 | 1 | - |
| CHEMBL564085 | TROLEANDOMYCIN | 4.0 | 1 | - |
| CHEMBL601773 | DIHYDROERGOCRISTINE | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL493 | BROMOCRIPTINE | Ki | = | 2810.0 | nM | 5.55 |
| CHEMBL160 | CYCLOSPORINE | Ki | = | 4660.0 | nM | 5.33 |
| CHEMBL772 | RESERPINE | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL1403281 | ERGOCRYPTINE | Ki | = | 12200.0 | nM | 4.91 |
| CHEMBL157101 | KETOCONAZOLE | Ki | = | 24900.0 | nM | 4.60 |
| CHEMBL446315 | ERGOCRISTINE | Ki | = | 42800.0 | nM | 4.37 |
| CHEMBL104 | CLOTRIMAZOLE | Ki | = | 44000.0 | nM | 4.36 |
| CHEMBL91 | MICONAZOLE | Ki | = | 55500.0 | nM | 4.26 |
| CHEMBL442 | ERGOTAMINE | Ki | = | 98900.0 | nM | 4.00 |
| CHEMBL119443 | ERGONOVINE | Ki | = | 115500.0 | nM | - |
| CHEMBL1385840 | ERGOCORNINE | Ki | = | 105200.0 | nM | - |
| CHEMBL1743263 | DIHYDROERGOCRYPTINE | Ki | = | 360500.0 | nM | - |
| CHEMBL1732 | DIHYDROERGOTAMINE | Ki | > | 1000000.0 | nM | - |
| CHEMBL532 | ERYTHROMYCIN | Ki | > | 1000000.0 | nM | - |
| CHEMBL106 | FLUCONAZOLE | Ki | > | 1000000.0 | nM | - |
| CHEMBL564085 | TROLEANDOMYCIN | Ki | = | 483300.0 | nM | - |
| CHEMBL601773 | DIHYDROERGOCRISTINE | Ki | = | 511000.0 | nM | - |