Assay Detail
Functional
CHEMBL2076249
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TP_TRANSPORTER: drug resistance (vincristine) in AML-2/D100 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | AML-2/D100 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.62 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 6.40 |
| CHEMBL2074901 | — | — | 1 | 6.40 |
| CHEMBL370963 | — | — | 1 | 6.05 |
| CHEMBL91153 | 3',4'-DIMETHOXYFLAVONE | — | 1 | 5.92 |
| CHEMBL13473 | 7,3',4'-Trimethoxyflavone | — | 1 | 5.92 |
| CHEMBL1087720 | TRIMETHYLAPIGENIN | — | 1 | 5.85 |
| CHEMBL2074919 | — | — | 1 | 5.72 |
| CHEMBL75258 | — | — | 1 | 5.50 |
| CHEMBL226507 | SINENSETIN | — | 1 | 5.50 |
| CHEMBL575072 | — | — | 1 | 5.20 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 4.71 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2074901 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL370963 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL91153 | 3',4'-DIMETHOXYFLAVONE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL13473 | 7,3',4'-Trimethoxyflavone | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL1087720 | TRIMETHYLAPIGENIN | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL2074919 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL75258 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL226507 | SINENSETIN | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL575072 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL50 | QUERCETIN | IC50 | = | 52500.0 | nM | 4.28 |