Assay Detail
Functional
CHEMBL2076478
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TP_TRANSPORTER: inhibition of Pravastatin uptake in Oat3-expressing LLC-PK1 cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | LLC-PK1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Functional involvement of rat organic anion transporter 3 (rOat3; Slc22a8) in the renal uptake of organic anions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 4.90 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2074600 | DIBROMOSULFOPHTHALEIN | — | 1 | 5.51 |
| CHEMBL29 | PENICILLIN G | 4.0 | 1 | 4.28 |
| CHEMBL463 | AMINOHIPPURIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2074600 | DIBROMOSULFOPHTHALEIN | Ki | = | 3090.0 | nM | 5.51 |
| CHEMBL29 | PENICILLIN G | Ki | = | 52800.0 | nM | 4.28 |
| CHEMBL463 | AMINOHIPPURIC ACID | Ki | = | 1350000.0 | nM | - |