Assay Detail
Functional
CHEMBL2076896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition pramipexole uptake in rOCT1-injected oocytes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 1 (CHEMBL2073670) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.62 | 5.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL640 | PROCAINAMIDE | 4.0 | 1 | 5.11 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 4.12 |
| CHEMBL110739 | CORTICOSTERONE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL640 | PROCAINAMIDE | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL660 | AMANTADINE | IC50 | = | 76300.0 | nM | 4.12 |
| CHEMBL110739 | CORTICOSTERONE | IC50 | = | 163700.0 | nM | - |