Assay Detail
Functional
CHEMBL2077067
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of DHEAS in membrane vesicles from MRP4-expressing Sf9 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Sf9 |
| Subcellular | Membrane vesicle |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
ATP-binding cassette sub-family C member 4 (CHEMBL1743128) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.60 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162492 | ESTRADIOL DISULFATE | — | 1 | 6.70 |
| CHEMBL1697724 | ESTRADIOL 17B GLUCURONIDE | — | 1 | 4.52 |
| CHEMBL3349339 | — | — | 1 | 4.16 |
| CHEMBL2074591 | — | — | 1 | 4.10 |
| CHEMBL2074982 | — | — | 1 | 4.10 |
| CHEMBL494753 | ESTRONE SULFURIC ACID | 4.0 | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162492 | ESTRADIOL DISULFATE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1697724 | ESTRADIOL 17B GLUCURONIDE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL3349339 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2074591 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL2074982 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL494753 | ESTRONE SULFURIC ACID | IC50 | = | 95000.0 | nM | 4.02 |