Assay Detail
Functional
CHEMBL2077082
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TP_TRANSPORTER: inhibition of ES uptake (ES: 50nM) in rOAT3-expressing S2 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | S2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.78 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL897 | PROBENECID | 4.0 | 1 | 5.22 |
| CHEMBL1144 | PRAVASTATIN | 4.0 | 1 | 4.81 |
| CHEMBL1231530 | BETAMIPRON | 2.0 | 1 | 4.32 |
| CHEMBL30 | CIMETIDINE | 4.0 | 1 | - |
| CHEMBL766 | CILASTATIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL897 | PROBENECID | IC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL1144 | PRAVASTATIN | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL1231530 | BETAMIPRON | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL30 | CIMETIDINE | IC50 | = | 166000.0 | nM | - |
| CHEMBL766 | CILASTATIN | IC50 | = | 742000.0 | nM | - |