Assay Detail
Functional
CHEMBL2077545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake (TEA: 100 uM) in Xenopus laevis oocytes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 2 (CHEMBL1770032) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Molecular mechanisms of organic cation transport in OCT2-expressing Xenopus oocytes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.86 | 4.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1197556 | — | — | 1 | 4.86 |
| CHEMBL11978 | NICOTINYL METHYLAMIDE | -1.0 | 1 | - |
| CHEMBL920 | CHOLINE | 0.5 | 1 | - |
| CHEMBL30 | CIMETIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1197556 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL11978 | NICOTINYL METHYLAMIDE | IC50 | = | 1560000.0 | nM | - |
| CHEMBL920 | CHOLINE | IC50 | = | 159000.0 | nM | - |
| CHEMBL30 | CIMETIDINE | IC50 | = | 373000.0 | nM | - |