Assay Detail
Functional
CHEMBL2077552
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of E217betaG uptake in membrane vesicle from MRP3-expressing Sf9 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | Sf9 |
| Subcellular | Membrane vesicle |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance associated protein (CHEMBL2073669) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Transport activity of human MRP3 expressed in Sf9 cells: comparative studies with rat MRP3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.25 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2074599 | E3040 GLUCURONIDE | — | 1 | 5.25 |
| CHEMBL493586 | — | — | 1 | - |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
| CHEMBL213947 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2074599 | E3040 GLUCURONIDE | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL493586 | — | Ki | = | 105000.0 | nM | - |
| CHEMBL34259 | METHOTREXATE | Ki | = | 1200000.0 | nM | - |
| CHEMBL213947 | — | Ki | = | 337000.0 | nM | - |