Assay Detail
Functional
CHEMBL2077571
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake (in the absence of bicarbonate) (TEA: 20 uM) in OCT1-expressing HEK293 cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 1 (CHEMBL2073670) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.74 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2074851 | Cyanine-863 | — | 1 | 6.35 |
| CHEMBL170 | QUININE | 4.0 | 1 | 5.96 |
| CHEMBL640 | PROCAINAMIDE | 4.0 | 1 | 4.92 |
| CHEMBL660 | AMANTADINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2074851 | Cyanine-863 | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL170 | QUININE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL640 | PROCAINAMIDE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL660 | AMANTADINE | IC50 | = | 280000.0 | nM | - |