Assay Detail
Functional
CHEMBL2078135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake in OCT2-expressing MDCK cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 2 (CHEMBL1770032) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.76 | 5.33 |
Compounds Tested
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL945 | AMILORIDE | Ki | = | 4700.0 | nM | 5.33 |
| CHEMBL517 | DISOPYRAMIDE | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL640 | PROCAINAMIDE | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL679 | EPINEPHRINE | Ki | = | 1191000.0 | nM | - |
| CHEMBL90 | HISTAMINE | Ki | = | 171000.0 | nM | - |
| CHEMBL39 | SEROTONIN | Ki | = | 242000.0 | nM | - |
| CHEMBL59 | DOPAMINE | Ki | = | 347000.0 | nM | - |
| CHEMBL1547 | THIAMINE ION | Ki | = | 646000.0 | nM | - |