Assay Detail
Functional
CHEMBL2078142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake in OCT1-expressing MDCK cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 1 (CHEMBL2073670) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.57 | 5.16 |
Compounds Tested
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL945 | AMILORIDE | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL640 | PROCAINAMIDE | Ki | = | 47000.0 | nM | 4.33 |
| CHEMBL517 | DISOPYRAMIDE | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL90 | HISTAMINE | Ki | = | 141000.0 | nM | - |
| CHEMBL679 | EPINEPHRINE | Ki | = | 1600000.0 | nM | - |
| CHEMBL39 | SEROTONIN | Ki | = | 390000.0 | nM | - |
| CHEMBL59 | DOPAMINE | Ki | = | 603000.0 | nM | - |
| CHEMBL1547 | THIAMINE ION | Ki | = | 736000.0 | nM | - |