Assay Detail
Functional
CHEMBL2078145
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Taurocholate uptake in NTCP-expressing HeLa cells
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HeLa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Hepatic sodium/bile acid cotransporter (CHEMBL5287) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Modulation by drugs of human hepatic sodium-dependent bile acid transporter (sodium taurocholate cotransporting polypeptide) activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.31 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 6.00 |
| CHEMBL1551 | URSODIOL | 4.0 | 1 | 5.44 |
| CHEMBL224867 | TAUROCHOLIC ACID | — | 1 | 5.28 |
| CHEMBL27 | PROPRANOLOL | 4.0 | 1 | 5.26 |
| CHEMBL452861 | LEVOPROPRANOLOL | 2.0 | 1 | 5.21 |
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | -1.0 | 1 | 5.14 |
| CHEMBL35 | FUROSEMIDE | 4.0 | 1 | 4.82 |
| CHEMBL157101 | KETOCONAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1551 | URSODIOL | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL224867 | TAUROCHOLIC ACID | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL27 | PROPRANOLOL | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL452861 | LEVOPROPRANOLOL | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL453904 | SULFOBROMOPHTHALEIN SODIUM | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL35 | FUROSEMIDE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 264000.0 | nM | - |