Assay Detail
Functional
CHEMBL2078544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of Tetramethylrosamine efflux in NIH-3T3-G185 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | NIH-3T3-G185 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.99 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | 4.0 | 1 | 5.68 |
| CHEMBL772 | RESERPINE | 4.0 | 1 | 5.28 |
| CHEMBL1484 | NICARDIPINE | 4.0 | 1 | 4.93 |
| CHEMBL1741 | CLARITHROMYCIN | 4.0 | 1 | 4.62 |
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 4.42 |
| CHEMBL170 | QUININE | 4.0 | 1 | - |
| CHEMBL50588 | EMETINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160 | CYCLOSPORINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL772 | RESERPINE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL1484 | NICARDIPINE | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL1741 | CLARITHROMYCIN | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL6966 | VERAPAMIL | IC50 | = | 38200.0 | nM | 4.42 |
| CHEMBL170 | QUININE | IC50 | = | 184900.0 | nM | - |
| CHEMBL50588 | EMETINE | IC50 | = | 207100.0 | nM | - |