Assay Detail
Functional
CHEMBL2078583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: drug resistance (paclitaxel) in MES-SA/DX5 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MES-SA/Dx5 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Differential effects of the optical isomers of KR30031 on cardiotoxicity and on multidrug resistance reversal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.21 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | 4.0 | 1 | 5.32 |
| CHEMBL36148 | (S)-VERAPAMIL | — | 1 | 5.27 |
| CHEMBL197 | DEXVERAPAMIL | 2.0 | 1 | 5.26 |
| CHEMBL2074950 | — | — | 1 | 5.18 |
| CHEMBL2074952 | — | — | 1 | 5.12 |
| CHEMBL2074951 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6966 | VERAPAMIL | IC50 | = | 4780.0 | nM | 5.32 |
| CHEMBL36148 | (S)-VERAPAMIL | IC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL197 | DEXVERAPAMIL | IC50 | = | 5520.0 | nM | 5.26 |
| CHEMBL2074950 | — | IC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL2074952 | — | IC50 | = | 7630.0 | nM | 5.12 |
| CHEMBL2074951 | — | IC50 | = | 7650.0 | nM | 5.12 |