Assay Detail
Functional
CHEMBL2089541
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Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum F-32 Tanzania assessed as inhibition of parasitemia after 3 days
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antimalarial activity of new haemanthamine-type derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 4.79 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.40 |
| CHEMBL2087272 | — | — | 1 | 6.10 |
| CHEMBL1172881 | HAEMANTHIDINE | — | 1 | 5.92 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | — | 1 | 5.89 |
| CHEMBL2087250 | — | — | 1 | 5.80 |
| CHEMBL2087264 | — | — | 1 | 5.54 |
| CHEMBL2087273 | — | — | 1 | 5.52 |
| CHEMBL2087271 | — | — | 1 | 5.29 |
| CHEMBL2087257 | — | — | 1 | 5.19 |
| CHEMBL2087274 | — | — | 1 | 5.16 |
| CHEMBL2087263 | — | — | 1 | 5.15 |
| CHEMBL469648 | VITTATINE | — | 1 | 5.14 |
| CHEMBL2087249 | — | — | 1 | 5.08 |
| CHEMBL2087256 | — | — | 1 | 5.00 |
| CHEMBL2087241 | — | — | 1 | 4.88 |
| CHEMBL2087254 | — | — | 1 | 4.87 |
| CHEMBL2087247 | — | — | 1 | 4.36 |
| CHEMBL2087246 | — | — | 1 | 4.29 |
| CHEMBL2087265 | — | — | 1 | 4.28 |
| CHEMBL2087262 | — | — | 1 | 4.28 |
| CHEMBL2087248 | — | — | 1 | 4.25 |
| CHEMBL2087258 | — | — | 1 | 4.20 |
| CHEMBL2087259 | — | — | 1 | 4.14 |
| CHEMBL2087268 | — | — | 1 | 4.14 |
| CHEMBL2087260 | — | — | 1 | 4.13 |
| CHEMBL2087251 | — | — | 1 | 4.13 |
| CHEMBL2087267 | — | — | 1 | 4.12 |
| CHEMBL2087244 | — | — | 1 | 4.12 |
| CHEMBL2087243 | — | — | 1 | 4.12 |
| CHEMBL2087269 | APOHAEMANTHIDINE | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76 | CHLOROQUINE | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2087272 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1172881 | HAEMANTHIDINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL401114 | (+)-HAEMANTHAMINE | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2087250 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2087264 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL2087273 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2087271 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL2087257 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL2087274 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2087263 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL469648 | VITTATINE | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL2087249 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL2087256 | — | IC50 | = | 9900.0 | nM | 5.00 |
| CHEMBL2087241 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL2087254 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL2087247 | — | IC50 | = | 43300.0 | nM | 4.36 |
| CHEMBL2087246 | — | IC50 | = | 51700.0 | nM | 4.29 |
| CHEMBL2087262 | — | IC50 | = | 52300.0 | nM | 4.28 |
| CHEMBL2087265 | — | IC50 | = | 52500.0 | nM | 4.28 |
| CHEMBL2087248 | — | IC50 | = | 56600.0 | nM | 4.25 |
| CHEMBL2087258 | — | IC50 | = | 62600.0 | nM | 4.20 |
| CHEMBL2087259 | — | IC50 | = | 72600.0 | nM | 4.14 |
| CHEMBL2087268 | — | IC50 | = | 72100.0 | nM | 4.14 |
| CHEMBL2087260 | — | IC50 | = | 73400.0 | nM | 4.13 |
| CHEMBL2087251 | — | IC50 | = | 73500.0 | nM | 4.13 |
| CHEMBL2087243 | — | IC50 | = | 75500.0 | nM | 4.12 |
| CHEMBL2087244 | — | IC50 | = | 75800.0 | nM | 4.12 |
| CHEMBL2087267 | — | IC50 | = | 76600.0 | nM | 4.12 |
| CHEMBL2087269 | APOHAEMANTHIDINE | IC50 | = | 84200.0 | nM | 4.08 |
| CHEMBL2087266 | — | IC50 | = | 85700.0 | nM | 4.07 |
| CHEMBL6067661 | — | IC50 | = | 91500.0 | nM | 4.04 |
| CHEMBL2087253 | APOHAEMANTHAMINE | IC50 | = | 92900.0 | nM | 4.03 |
| CHEMBL2087252 | — | IC50 | = | 95500.0 | nM | 4.02 |
| CHEMBL2087261 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2087255 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2087270 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2087245 | — | IC50 | > | 100000.0 | nM | - |