Assay Detail
Functional
CHEMBL2089717
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at PPARalpha-LBD expressed in HEK293 cells co-expressing GAL4-DBD after 16 to 19 hrs by beta lactamase reporter gene assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.21 | 9.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088421 | — | — | 1 | 9.55 |
| CHEMBL21241 | GW7647 | — | 1 | 9.34 |
| CHEMBL2088422 | — | — | 1 | 9.23 |
| CHEMBL20392 | — | — | 1 | 8.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088421 | — | IC50 | = | 0.28 | nM | 9.55 |
| CHEMBL21241 | GW7647 | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL2088422 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL20392 | — | IC50 | = | 1.93 | nM | 8.71 |