Assay Detail
Binding
CHEMBL2090106
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Pseudomonas aeruginosa MBL IMP-1 using nitrocefin as substrate preincubated for 20 mins by UV-spectrophotometric analysis
20
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 4.78 | 5.30 |
| Ki | 2 | 5.55 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | 4.0 | 2 | 5.62 |
| CHEMBL2087628 | — | — | 2 | 5.48 |
| CHEMBL1722922 | — | — | 1 | 4.46 |
| CHEMBL2087633 | — | — | 1 | 4.11 |
| CHEMBL1406848 | — | — | 1 | - |
| CHEMBL2087323 | — | — | 1 | - |
| CHEMBL2087629 | — | — | 1 | - |
| CHEMBL2087630 | — | — | 1 | - |
| CHEMBL154191 | — | — | 1 | - |
| CHEMBL2087631 | — | — | 1 | - |
| CHEMBL2087632 | — | — | 1 | - |
| CHEMBL2087634 | — | — | 1 | - |
| CHEMBL2087635 | — | — | 1 | - |
| CHEMBL79962 | — | — | 1 | - |
| CHEMBL2086406 | — | — | 1 | - |
| CHEMBL2087636 | — | — | 1 | - |
| CHEMBL2087637 | — | — | 1 | - |
| CHEMBL2087638 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1560 | CAPTOPRIL | Ki | = | 2400.0 | nM | 5.62 |
| CHEMBL2087628 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL1560 | CAPTOPRIL | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2087628 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL1722922 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL2087633 | — | IC50 | = | 77000.0 | nM | 4.11 |
| CHEMBL1406848 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087323 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087638 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087637 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087636 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2086406 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL79962 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087635 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087634 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087632 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087631 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL154191 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087630 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL2087629 | — | IC50 | > | 200000.0 | nM | - |