Assay Detail
Binding
CHEMBL2090414
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Inhibition of HIV1 gp120 expressed in human HL2/3 cells assessed as Hl2/3 cell fusion to compound-treated human TZM-bl cells after 48 hrs by luciferase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.80 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088494 | — | — | 1 | 5.80 |
| CHEMBL186141 | ANDROGRAPHOLIDE | 3.0 | 1 | - |
| CHEMBL2088490 | — | — | 1 | - |
| CHEMBL2088492 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088494 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | - | — | - | |
| CHEMBL2088490 | — | IC50 | - | — | - | |
| CHEMBL2088492 | — | IC50 | - | — | - |