Assay Detail
Binding
CHEMBL2090421
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Inhibition of Bcl-XL-BAK interaction
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Lipophilic Isosteres of a π-π Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.15 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2089293 | — | — | 1 | 6.66 |
| CHEMBL2089288 | — | — | 1 | 6.24 |
| CHEMBL2089290 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2089293 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2089288 | — | EC50 | = | 580.0 | nM | 6.24 |
| CHEMBL2089290 | — | EC50 | = | 2850.0 | nM | 5.54 |