Assay Detail
Binding
CHEMBL2090789
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human 6x-His tagged BRAF V600E mutant expressed in Sf9 cells by ELISA based kinase assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of a novel family of BRAF(V600E) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.40 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2030274 | — | — | 1 | 7.10 |
| CHEMBL2030272 | — | — | 1 | 7.00 |
| CHEMBL2087793 | — | — | 1 | 6.92 |
| CHEMBL2088028 | — | — | 1 | 6.85 |
| CHEMBL2088021 | — | — | 1 | 6.85 |
| CHEMBL2030281 | — | — | 1 | 6.82 |
| CHEMBL2087792 | — | — | 1 | 6.72 |
| CHEMBL2088018 | — | — | 1 | 6.72 |
| CHEMBL2088022 | — | — | 1 | 6.68 |
| CHEMBL2030271 | — | — | 1 | 6.60 |
| CHEMBL2088019 | — | — | 1 | 6.55 |
| CHEMBL2087788 | — | — | 1 | 6.52 |
| CHEMBL2030469 | — | — | 1 | 6.50 |
| CHEMBL2030468 | — | — | 1 | 6.42 |
| CHEMBL581146 | — | — | 1 | 6.40 |
| CHEMBL2088026 | — | — | 1 | 6.28 |
| CHEMBL2087789 | — | — | 1 | 6.22 |
| CHEMBL2088027 | — | — | 1 | 6.17 |
| CHEMBL2087787 | — | — | 1 | 6.16 |
| CHEMBL2088020 | — | — | 1 | 6.14 |
| CHEMBL2088024 | — | — | 1 | 6.14 |
| CHEMBL2087791 | — | — | 1 | 6.10 |
| CHEMBL2087790 | — | — | 1 | 6.05 |
| CHEMBL2088023 | — | — | 1 | 5.80 |
| CHEMBL2088025 | — | — | 1 | 5.44 |
| CHEMBL1342041 | — | — | 1 | 5.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2030274 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2030272 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2087793 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL2088028 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2088021 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2030281 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2087792 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2088018 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2088022 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2030271 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL2088019 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2087788 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2030469 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2030468 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL581146 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2088026 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL2087789 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2088027 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2087787 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2088020 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2088024 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL2087791 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2087790 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2088023 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL2088025 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL1342041 | — | IC50 | = | 6100.0 | nM | 5.21 |